For West Ham fans, it doesn't come much bigger than a derby against Tottenham Hotspur.
Slaven Bilic's side only really have pride left to play for at the end of what's been a disappointing first season at the London Stadium.
Yet, for the supporters, finishing off Spurs' slim title hopes would almost make the whole campaign worthwhile.
When the two sides met in the reverse fixture at White Hart Lane, two goals from Harry Kane in the 89th and 91st minute secured a remarkable turnaround and a 3-2 win for the Lilywhites.
This is the Hammers' chance not only to avenge that, but also to put a run of form together and end the season on a high.
The Metropolitan Police probably aren't too pleased that the game's being staged on a Friday night, but for the rest of us, it should make entertaining viewing.
No-one is seemingly looking forward to the encounter more than Bobby Zamora, who has a particular interest in the game having played for both teams at different stages of his career.
However, the striker made it very clear who he'll be cheering for with this tweet:
The problem with posting something like that on social media is that it is bound to get a reaction.
It's especially likely to invite tweets from angry Spurs fans, given how his career in north London actually panned out.
Not exactly a Spurs icon...
As Zamora rightly says, he did score a goal against West Ham. It was in the League Cup back in 2003, and it sent Tottenham through in extra time.
Unfortunately, that was the first and last goal he ever scored for the club. In 17 other appearances, he failed to find the back of the net and ended up - well, being sold to West Ham.
It's not uncommon for the two clubs to share players despite their rivalry, but it's been a fairly one-sided relationship; while Spurs have taken the likes of Jermain Defoe and Michael Carrick from east London, they have given them Matthew Etherington and Zamora in return.
Few will have lost any sleep about that last deal, and it wasn't long before Zamora was getting roasted:
On one of the occasions pictured when he did score against Spurs, it looked to be the winner - but Dimitar Berbatov and Paul Stalteri quickly hit back to seal a 4-2 victory for the visitors.
Bilic will be hoping to avoid any similar heartbreak tonight, but even if his side win, Zamora should probably keep his head down.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms