Hugo Rodallega scored two goals to help his Wigan side end Burnley's 100% record at Turf Moor since stepping up to the Barclays Premier League.
The Colombia striker, fast becoming the Latics' lucky talisman, has now scored five goals this season, with all four of Wigan's wins coming when he has been on the scoresheet.
After cancelling out Steven Fletcher's fourth-minute opener after an unlucky Brian Jensen fell to the floor injured, Rodallega added his second early after the restart. That was before a rare Emmerson Boyce strike sealed Wigan a first away win since the opening day of the campaign.
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