Tranmere caretaker boss Les Parry is hoping to make at least one loan signing ahead of the home clash with Southend.
Key defender Ian Goodison was forced off with a back injury in the first half of Saturday`s 2-1 defeat at Leyton Orient and could miss out.
Shaleum Logan (groin injury) and Gareth Edds (chickenpox) played no part at the weekend and could also remain sidelined.
Parry has been given the green light by chairman Peter Johnson to begin searching for new players as Rovers seek to breath new life into their fight against relegation.
Parry said: "I have gone ahead and made inquiries about two or three players. If the clubs come back to me and say they are willing to let those players come here, then I will ask the chairman to fund it."
Southend midfielder Anthony Grant will be suspended for the trip to Prenton Park.
Grant will serve the first of a two-match ban after picking up his 10th booking in just 20 matches against MK Dons at the weekend.
New loan signing Sean Morrison returns to the squad after serving a one-match suspension following his first-half dismissal against Yeovil on his debut.
Fellow loanee Jean-Yves M'voto is still sidelined after undergoing a hip operation, while Osei Sankofa (knee) is also missing from Southend's defence.
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