Preston boss Alan Irvine will have to decide whether to deploy Eddie Nolan or Liam Chilvers in place of the injured Youl Mawene against Derby.
The Frenchman is sidelined for several months after damaging knee ligaments in North End's recent defeat at the hands of Newcastle.
Nolan impressed during the draw at Blackpool and earned himself a ringing endorsement from Irvine but was replaced by Chilvers against Cardiff at the weekend.
Chilvers, who revealed on Monday his absence from last week's derby was due to suspected swine flu, admitted he struggled at Cardiff but feels he is back to full fitness again.
He said: "I came back to training last Thursday and felt like someone had stolen my lungs. At Cardiff I was okay, a little bit tired towards the end of the game, but it was nice to be back playing again."
Midfielder Barry Nicholson remains a long-term absentee as Preston look to end a run of six games without a win.
Derby manager Nigel Clough will have to cope without defender Shaun Barker for the trip.
Barker is ruled out with a thigh injury, which also kept him out of Saturday's draw with West Brom.
The 27-year-old is also expected to miss Saturday's clash with Watford at Vicarage Road.
The injury to Barker means former Blackburn defender Jay McEveley will deputise once again at centre-half.
However, Clough has better news regarding the fitness of midfielder Paul Green.
Green has been sent for a precautionary scan after complaining of tight hamstrings but will travel with the team in case he is ruled fit.
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms