Grayson has no new injury or suspension problems and has drawn a line under his spat with leading goalscorer Jermaine Beckford following the striker's refusal to shake hands with his manager when substituted during last weekend's home win over Southampton.
Beckford is expected to start again alongside Luciano Becchio up front, while on-loan pair Sam Vokes and Tony Capaldi will be hoping to make the matchday squad after missing out altogether last weekend.
Richard Naylor and Patrick Kisnorbo are likely to resume in central defence, while midfielder Bradley Johnson and Max Gradel, on loan from Leicester, will be hoping to play bigger roles as Leeds bid to extend their four-point lead at the top.
Hartlepool will be without Andy Monkhouse. The winger, who scored Pools' equaliser in last weekend`s 1-1 draw at home to Yeovil, was booked for the fifth time this season in that game and must now serve a one-match ban against his hometown club.
However, director of sport Chris Turner hopes to have full-back Neil Austin available after a hamstring problem, meaning Antony Sweeney would be able to stand in for Monkhouse.
Ben Clark is available after completing a one-match suspension for his dismissal at Southend.
Colin Larkin returned to training this week after a hamstring injury of his own but he is unlikely to feature, while Steve Haslam is also edging closer to fitness after a hernia problem but the Leeds game may come too soon.
Striker Denis Behan is around a fortnight away from a return to training, but James Brown (knee) remains a long-term absentee.
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