Grimsby will be without on-loan defender Oliver Lancashire for their home League Two clash with Bury.
The 21-year-old defender, who has made 10 appearances for the club, has been recalled to Southampton because of an injury crisis at St Mary's.
Lancashire's departure means Paul Linwood and Rob Atkinson are set to line up in central defence.
Ben Wright has also left the club, returning to Peterborough after making two appearances during his loan period.
Defender Joe Widdowson made his comeback from a foot injury with a second-half appearance in the 2-1 defeat to Port Vale on Monday.
Nathan Jarman will be pushing for a starting place after another successful substitute appearance following his recovery from a foot injury.
But the game is likely to come too soon for new signing Mark Hudson, who continues his recovery from a hamstring injury.
Bury boss Alan Knill is boosted by the return of striker Tom Elliott ahead of the trip.
Elliott is available after re-joining on loan from Leeds.
Andy Bishop, Damian Allen and Ryan Cresswell are approaching full fitness after injury and could also play some part at Blundell Park.
That would leave forward Danny Carlton as the only injury absentee.
Carlton is expected back in late January to early February as he recovers from a serious Achilles injury.
Knill is expecting his players to step up their promotion challenge now that players are returning from injury.
The Shakers are only out of the play-off places on goal difference and Knill said: "Now there are no excuses because we have players back."
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