Northampton manager Ian Sampson will have new signings Luke Wilkinson and Stephen O'Flynn available for the visit of Chesterfield.
Defender Wilkinson has arrived on loan from Portsmouth while striker O'Flynn has signed until the end of the season from Irish side Limerick and both could feature against the Spireites.
Full-back Paul Rodgers returns after missing the excellent 2-0 win at Bournemouth last weekend thanks to a one-match suspension but is likely to have to settle for a place on the bench.
Winger Liam Davis remains sidelined with his foot injury while striker Steve Guinan could be out for another fortnight with his groin problem.
Sampson will be looking to extend the club's unbeaten run to six games as the platform for an improbable surge toward the play-off places.
Chesterfield boss John Sheridan will be without Drew Talbot for the clash.
The forward was carried off on a stretcher after just 26 minutes of last weekend's 1-0 home defeat by Shrewsbury with an ankle problem, but X-rays have revealed that he has not broken any bones. However, the club suspect that the injury could be ligament damage, so Talbot is set to see a specialist on Friday.
Jack Lester will be hoping to return to the Spireites attack after recovering from an ankle knock but he will have to compete with Scott Boden, who made his first start of the season against Shrewsbury, and Wade Small for one of the two starting spots.
Aaron Downes staked his claim for a starting berth after playing the full 90 minutes against Shrewsbury, in what was his first appearance since suffering a knee injury in April.
On-loan trio Mark Little, David Perkins and Davide Somma will not feature after returning to their parent clubs, while Kieran Djilali is set to play the final game of his loan spell before going back to Crystal Palace.
Meanwhile, Sheridan can call on Danny Hall and Paul Harsley after the duo returned from their respective loan spells, but Jordan Bowery (ankle) is unavailable.
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