Liam Trotter is in line to make his second Millwall debut when Southampton visit The Den.
The midfielder arrived on loan from Ipswich last week, having previously played for the Lions in 2006, but was ineligible for Tuesday night's FA Cup replay defeat at Derby.
Tony Craig will be checked over after missing out at Pride Park with an ankle injury and fellow defender Andy Frampton is a doubt after limping off.
Striker Lewis Grabban also had to come off in midweek with a suspected hamstring strain, leaving the Lions light in attack with Gary Alexander (heel) and Neil Harris (back) still sidelined.
Scott Barron and Danny Schofield came off the bench at Derby and could be handed starting roles.
Radhi Jaidi has been ruled out of Southampton's trip to London.
The experienced defender has visited a specialist after suffering an eye injury in training and is expected to be out for around a fortnight.
Jaidi's absence could result in an immediate debut for Jose Fonte, who has joined from Crystal Palace, or Dan Seaborne following his switch from Exeter.
Right-back Jon Otsemobor is also in line to feature after arriving a six-month contract from Norwich as cover for ankle injury-victim Graeme Murty.
Striker David Connolly is rated 50-50 with the groin injury which forced him to miss the FA Cup win over Luton last time out.
Senegalese frontman Papa Waigo will partner 21-goal Rickie Lambert in attack if Connolly is ruled out.
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