If Manchester City aren't going to run away with the Premier League title, it looks like it will be up to either Manchester United or Tottenham to stop them.

Pep Guardiola's men have the chance to steal a march on their rivals this weekend, as Jose Mourinho and Mauricio Pochettino's respective sides meet at Old Trafford in Saturday's early kick-off.

Pochettino is once again attracting deserved plaudits for getting his side to compete with the top teams on a fraction of their budget.

And judging by the Lilywhites' away form, there's no reason why they shouldn't go to United and attack.

There's not an awful lot between the two, and putting together a combined XI has been no easy task. To make things simpler, we're just going off the players who are likely to be fit - which as it stands, excludes Harry Kane, as the Tottenham striker is a major doubt.

Paul Pogba will also miss out despite returning to training over the past few days.

David de Gea

While Hugo Lloris grabbed headlines with his incredible saves against Real Madrid and Liverpool, there are few who would dispute that De Gea is still the Premier League's number one.

Antonio Valencia

“He is simply the best right-back you can have, there is no better right-back in football," Mourinho said last season, per the Independent. Probably a slight exaggeration, yet his pace down the wing gives United a dimension they might otherwise be lacking.

Toby Alderweireld

Admittedly, the Belgian didn't have his best performance in the Carabao Cup defeat to West Ham. Alderweireld is one of the most composed centre-backs around and his ability not to concede fouls is what's marked him apart in English football.

Jan Vertonghen

In their early days together, it looked as if Alderweireld was making Vertonghen a better player, but there's a solid argument that it's been the other way round this season.

Danny Rose

Prior to a knee injury sidelining him for nine months, Rose had established himself as England's first choice and was starting to attract interest from some of Europe's elite clubs - including United, if rumours are to be believed.

Nemanja Matic

The Serbian's final season at Chelsea left a little to be desired, but oddly enough, Mourinho has helped him recover his form. He's brought some much-needed stability to United's central midfield.

Mousa Dembele

Dembele's injury problems mean he's having to sit out more and more, but his runs forward and ability to hold onto the ball are a huge asset for Spurs.

Anthony Martial

Martial has quickly changed Mourinho's opinion of him with five goals and four assists in the early stages of the campaign.

Christian Eriksen

Eriksen is now the Premier League's highest-scoring Dane and the effortless way he makes Spurs' attack tick has finally started to earn him the attention he deserves.

Dele Alli

Alli has been involved in more goals by the age of 21 than the likes of Cristiano Ronaldo, Steven Gerrard, and David Beckham.

Romelu Lukaku

The fact that Kane may be forced to sit out has made this a little easier. Even if Lukaku is often accused of failing to turn up in big games, that shouldn't take anything away from him scoring 10 goals in 13 games this season.

Who should be in a United-Spurs combined XI? Have your say in the comments.