Fifth-placed Swindon tossed away their hopes of moving up the Coca-Cola League One table despite a lightning start in their 2-2 draw at Southend.
Billy Paynter gave the visitors a first-minute lead and Charlie Austin hit his 10th goal in 11 games to open up a 2-0 advantage with 10 minutes on the clock.
But Southend fought back at the death with Scott Spencer reducing the deficit in the 85th minute and debutant Pat Baldwin equalising with almost the last kick of the match.
Millwall stayed in the play-off positions by edging a 1-0 win over Brighton, whose appalling home form continued when Steve Morison snatched the only goal of the game in the 49th minute.
Southampton continued to climb the table with a 2-0 home win over rock-bottom Stockport, Ricky Lambert opening the scoring after 63 minutes and Papa Waigo securing Saints' seventh successive home win six minutes later.
MK Dons looked set to continue their play-off push after Sam Baldock gave them a 50th-minute led at home to Exeter. But Barry Corr's equaliser in the last minute helped ease the Grecians' relegation worries.
Wycombe gave their survival hopes a huge boost with an exciting 3-2 win at Bristol City with Stuart Beavon striking a dramatic 80th-minute winner.
Matt Harrold put the visitors ahead from the spot on 15 minutes but a quick double from Chris Lines just before the break had the home side back in control, but another penalty in the 48th minute - this time converted by Alex Revell - set up the grandstand finish and Beavon's strike which moved Wanderers three points off safety.
Leyton Orient battled back from 2-0 down to claim a point at Carlisle, with a second-half strike by Matt Jarvis and an own goal by Danny Livesey cancelling out first-half efforts from Joe Anyinsah and Ian Harte.
Loan star Nathan Eccleston hit the only goal of the game as Huddersfield won 1-0 at Yeovil, while Gillingham's Priestfield Stadium clash with Walsall ended goalless.
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