Swansea forward Cedric van der Gun will have a late fitness test ahead of Preston's visit to the Liberty Stadium.
The Dutchman is struggling with a hamstring problem and has been missing since the beginning of January. But last Saturday's postponment against Watford has given him extra time to recover and he could be in the frame.
Craig Beattie has sustained a foot injury and he too is doubtful, although boss Paulo Sousa is much more hopeful that the former West Brom man will make it.
Shefki Kuqi could be handed his first start in attack after making his Swans debut as a substitute at Coventry a fortnight ago, with Gorka Pintado potentially making way.
Joe Allen will be hoping to get the nod over Jordi Lopez in midfield but defender Albert Serran (hamstring) remains on the sidelines.
Preston boss Darren Ferguson will assess the fitness of midfielder Richard Chaplow ahead of the game.
Chaplow picked up a knock and was substituted after just 29 minutes of Tuesday's thumping 4-1 home defeat against Barnsley.
However, Ferguson has new signing Paul Coutts available for the trip to Wales and may be tempted to thrust him straight into the starting line-up.
The 21-year-old did not sign in time to be registered for Tuesday's clash, but looks almost certain to feature against the Swans.
Winger Keith Treacy made his debut off the bench against Barnsley and is pushing for a starting role on the right flank.
Callum Davidson is hoping to shake off a head injury to play but winger Paul Parry (knee) midfielder Barry Nicholson (broken leg) remain sidelined.
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms