Tranmere boss Les Parry will hand Aaron Cresswell a chance to re-establish himself in the side when Oldham visit Prenton Park.
First-choice left-back Zoumana Bakayogo was sent off in last Saturday's 1-1 draw at Charlton and now misses the visit of the Latics.
The French defender must serve a one-match ban and Parry said: "This is an opportunity for Aaron to take his chance."
On-loan Watford striker Marvin Sordell, who has made four first-team appearances for the Hornets this season, joined Rovers on a month's loan earlier this week.
He has impressed in training and could make his bow against Dave Penney's side.
Striker Bas Savage remains sidelined as he recovers from a 10-month lay-off with a ruptured Achilles tendon.
Oldham boss Dave Penney could hand a debut to on-loan striker Jason Price.
The 32-year-old, who has scored 79 goals in 334 appearances during a much-travelled career, has joined the Latics on a month`s loan from Millwall.
Defender Hasney Aljofree could also come into contention after he signed a permanent deal with the Latics following his departure from Swindon.
Crystal Palace goalkeeper Darryl Flahavan has rejoined Oldham on loan until the end of the season and will challenge Dean Brill for a starting berth.
The Latics have been further boosted after after Huddersfield midfielder Jim Goodwin agreed to stay at the club for the remainder of the campaign after joining on loan at the start of January.
His continued availability is a major boost as Jon Worthington, Andy Holdsworth, Kelvin Lomax, Rob Purdie and Lewis Alessandra all remain sidelined through injury.
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