Shrewsbury will be without Craig Disley and Shane Cansdell-Sherriff for the visit of second-placed Bournemouth.
Midfielder Disley, who has only recently returned from injury, is now facing up to eight weeks on the sidelines with a broken ankle sustained during Monday night's 1-1 draw at Rotherham.
Influential defender Cansdell-Sherriff picked up his 10th booking of the season at the Don Valley Stadium and will now serve a two-match suspension. His absence should pave the way for Dean Holden to return.
David Button is set to continue in goal as Shrews make the finishing touches to a deal that will see the on-loan Tottenham stopper remain at the Prostar until the end of the season.
Manager Paul Simpson will be more than desperate for victory against the Cherries to round off a crucial four-match period he felt would shape the club's promotion destiny.
Victory over Hereford has been followed up with defeat at Bury and a draw at Rotherham, meaning success over Bournemouth would make it a solid return of seven points from a possible 12.
Bournemouth will once again be without midfielder Danny Hollands and have only 13 fit professionals.
Hollands was ruled out of Tuesday night's 3-0 victory against Barnet after injuring his knee against Macclesfield on Saturday and he will also sit out the game this weekend.
The Cherries are still down to the bare bones, with Sammy Igoe sidelined with a hamstring injury and Joe Partington nursing a back problem.
Scott Guyett (knee), Shaun Cooper (hip) and Mark Molesley (foot) are all long-term absentees and the trio are targeting a return for the clash against Bradford on April 3.
On a more positive note, Ryan Garry came through 90 minutes against the Bees after recovering from a groin injury and suffered no reaction to the injury, while fellow defender Rhoys Wiggins has extended his loan spell from Norwich by a further 28 days.
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