Doncaster captain Brian Stock will miss his side's meeting with relegation rivals Crystal Palace due to a back problem.
The Wales midfielder struggled with the injury last season and was forced to undergo surgery, but the problem has now returned and is once again threatening to derail his campaign.
Stock is to visit a specialist on Friday to determine what course of treatment he should take.
Midfielder Martin Woods has a groin injury and defender Shelton Martis a hamstring problem and, although both are on the verge of resuming full training, neither will be involved against the Eagles.
Jason Shackell is back with parent club Wolves as he nurses a hernia problem, while Adam Lockwood (foot) is a long-term casualty.
Crystal Palace boss Neil Warnock is boosted by the return of three players for what could potentially be his last game in charge.
Warnock has been strongly linked with the vacant manager's job at QPR and would only confirm after Wednesday night's 3-1 FA Cup fifth-round replay defeat to Aston Villa that he will be in charge for at least one more game.
Striker Stern John, winger Kieron Cadogan and full-back Lee Hills all missed the defeat at Villa Park as they were cup-tied but the trio return to contention.
Midfielder Neil Danns passed a fitness test on a back injury to play virtually the whole match against Aston Villa on Wednesday night and is set to keep his place in the side.
Striker Sean Scannell was an unused substitute at Villa Park following a hamstring injury and is again available for selection.
Long-term absentee Paddy McCarthy is back in non-contact training as he continues his recovery from a shoulder problem.
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