David Connolly and Lloyd James could return to Southampton`s squad for the eagerly-anticipated visit of Leeds.
Striker Connolly has been sidelined since the turn of the year with a niggling groin problem while an ankle injury kept has midfielder James out for the past month.
But both have resumed full training this week and should be in the matchday party.
Winger Lee Holmes will be missing for another fortnight as he rests a groin problem and veteran full-back Graeme Murty is struggling to play again this season after undergoing ankle surgery last month.
Alan Pardew's side slipped 16 points off the play-off pace following last weekend's surprise defeat at Tranmere which brought their eight-match unbeaten run to a halt.
Leeds manager Simon Grayson has an almost full-strength squad at his disposal for the clash.
Grayson has no new injury or suspension problems following his side's 4-1 midweek win at Tranmere and both Richard Naylor (thigh) and Andrew Hughes (illness) came through unscathed after returning to action at Prenton Park.
Aston Villa defender Shane Lowry has missed the last two games due to a knee injury and has returned to his parent club for treatment.
The Australian's loan spell is due to expire after the Southampton game and Grayson has yet to decide whether to extend his deal.
Mike Grella remains sidelined with an unspecified injury, while midfielders Neil Kilkenny, Bradley Johnson and Max Gradel and new striker Paul Dickov are all hoping to play a bigger part as Leeds look to close the four-point gap on leaders Norwich.
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