Bolton will attempt to achieve what Liverpool could not manage, with boss Owen Coyle insisting he was not surprised that Wigan stunned the faltering Anfield giants.
Coyle's Bolton face a Reebok relegation showdown with Wigan, with their near-neighbours having produced a 1-0 win over Liverpool on Monday - a victory none of the other relegation fighters could have imagined, or wanted.
Coyle and the rest of the managers at the bottom of the Barclays Premier League would have expected Liverpool, despite their rocky season, to have won and the three points have given Wigan a major boost in their battle to avoid the drop.
The Scot said: "I suppose we all sat and watched that game wanting Liverpool to win. But now it has happened and Wigan have the points, it is not a result that surprised me one bit."
Coyle will have midfielder Tamir Cohen back from suspension, but has lost defender Sam Ricketts with a one-match ban after he was red-carded in the 4-0 defeat at Sunderland on Wednesday.
And the manager knows Wigan will be cock-a-hoop after their first victory over the Merseysiders.
He continued: "I was not a bit surprised by what Wigan did to Liverpool.
"Wigan were at home, they are a good side and they have also beaten Chelsea this season, so nothing surprises me in the Premier League, it is a very close competition.
"That has been seen this season. The top three, four or six - whatever you want to call them - have shown they are capable of losing games to teams lower down. It has happened too often this season for it to be a fluke."
Meanwhile, Roberto Martinez says Wigan have set the standard following their victory over the Reds - and challenged them to maintain it this weekend.
Latics moved four points clear of the relegation zone after beating Liverpool for the first time in their history, and face a real six-pointer at the Reebok.
After being massive underdogs against the Reds, Martinez is well aware the victory will have raised expectation levels ahead of the clash with the Trotters.
But he insists the players will be up to the test - provided they can keep up their performance levels.
Martinez said: "You can sometimes get a lucky result in football, but our performance against Liverpool was not lucky. It was the perfect performance.
"We were brave from the very first minute, and we showed a great determination to win the football match.
"To do that against a team like Liverpool shows what we are capable of and the talent in the squad - the challenge now is to show it on a consistent basis.
"We are quite a level-headed group, and we are already looking ahead to the Bolton game.
"The players know that if they do not repeat the performance from Monday night, then all that good work will have been for nothing."
Martinez has reported no fresh injury worries.
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