Radhi Jaidi could return to the Southampton side for the visit of Hartlepool.
The centre-half missed Saturday's 3-0 win at MK Dons with a hamstring tweak but manager Alan Pardew expects him to be available again.
The news is not so good for fellow defender Wayne Thomas, who will miss the Pools game and Sunday's Johnstone's Paint Trophy final showpiece at Wembley after tearing his calf in training.
Thomas has been filling in at right-back recently with Jon Otsemebor and Graeme Murty (both ankle) sidelined, so left-back Dan Harding was forced to switch flanks on Saturday.
Midfielder Lloyd James (ankle), who can also play at right-back, returned on the bench against the Dons and provides another option.
Striker David Connolly recovered from a groin injury to appear as late substitute and should be involved again.
Gary Liddle and Neil Austin head Chris Turner's injury worries as struggling Hartlepool make the trip south.
Liddle missed Friday's disappointing draw at Tranmere because of a groin strain, while fellow defender Austin limped out of the action with a back injury.
Ben Clark is expected to carry on in the heart of the defence if Liddle is ruled out, with Leon McSweeney deputising for Austin at full-back.
Turner could recall striker Adam Boyd to his starting line-up at St Mary's, with Pools in desperate need of a win as they look to boost their chances of survival.
They are currently just two points clear of the relegation zone and were beaten 3-1 by Southampton the last time the two sides met.
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