Brentford will be thin on the ground when Exeter visit Griffin Park on Easter Monday.
Ryan Dickson, who had been struggling with a hamstring problem, trained last week and managed to start Friday's 1-1 draw at Millwall.
But the midfielder lasted just 18 minutes before suffering another hamstring injury and manager Andy Scott admits he is unlikely to be fit to face the Grecians.
Kevin O'Connor was also substituted against the Lions and required stitches in his ankle, while Charlie MacDonald sustained a head injury.
Scott may struggle to name seven substitutes but admitted there were players who were putting themselves through the pain barrier.
The Bees boss, who will complete a two-match touchline ban for improper conduct, will again be without Mark Phillips (knee) and Nikki Bull (shoulder).
Stuart Fleetwood is set to start for Exeter.
Fleetwood came on as a 27th-minute substitute in Friday night's 2-0 home win over Colchester after utility player Rob Edwards was forced to leave the field with a hamstring injury.
And the striker's introduction proved pivotal as he opened the scoring before winning a late penalty, converted by Ryan Harley.
Fleetwood should therefore be handed a starting role at Griffin Park, but it remains to be seen whether Edwards will be fit to feature.
Grecians boss Paul Tisdale must continue to cope without Adam Stansfield, who remains sidelined with an abdominal problem.
Playmaker Alex Russell is also ruled out with a back injury as Exeter look to pull further clear of the relegation zone.
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