Manchester City left-back Wayne Bridge could face Manchester United in the derby on Saturday at Eastlands.
The defender has recovered from a hernia operation, which caused him to miss five matches. He is one of four players who are in line to return with Stephen Ireland (ankle) and Patrick Vieira (knee ) on the mend from injuries while Pablo Zabaleta is free from suspension.
Bridge has endured a troubled season off and on the pitch and only returned to action against Hull in February after missing 13 games because of a knee problem.
Mancini said: "We will have Pablo Zabaleta available again following his two-match ban and possibly Stephen Ireland, Patrick Vieira and Wayne Bridge too which is very good news for us."
He added: "I am very pleased they are back in training and we will see how things go this week."
Bridge has ruled himself out of England duty after allegations of an affair between his former girlfriend Vanessa Perroncel and Chelsea captain John Terry.
However manager Fabio Capello has left the door open for Bridge, who played alongside Terry at Chelsea, and Mancini also said he hopes his player changes his mind.
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