Exeter could recall experienced striker Marcus Stewart for their must-win game at home to promotion-chasing Huddersfield.
Stewart and Irish striker Barry Corr were introduced as 83rd-minute substitutes in last week's 1-1 draw at Hartlepool, where Richard Logan and on-loan Rotherham striker Ryan Taylor were preferred in attack.
However, boss Paul Tisdale is not averse to switching his line-ups and often operates a rotation policy when it comes to his forwards, especially if they have not won.
Corr shrugged off ankle and knee injuries to play a late part at Victoria Park but will be hoping for a recall to the starting line-up.
Stuart Fleetwood is also set to come into the frame should Tisdale opt to switch strikers.
Sixth-placed Huddersfield have already booked their play-off spot but City go into the last game of the season threatened by the drop.
Hartlepool's three-point deduction means they are just a point above Exeter while fourth-from-bottom Tranmere are on the same number of points as City but have a far inferior goal difference.
Huddersfield midfielder Michael Collins could return to boost Lee Clark's squad.
The Republic of Ireland Under-21 international has missed the last four matches after badly fracturing his finger during last month's 3-0 defeat at Brentford but has had the protective cast removed and could be included.
Town, assured of a play-off place, have an outside mathematical chance of snatching automatic promotion but must win and hope for a highly unlikely sequence of other results.
Clark has no other new injury or suspension problems and faces a selection dilemma up front.
Lee Novak pressed his claims for a return to the starting line-up with the late winner after stepping off the substitutes bench last week while Robbie Simpson is fit-again following a long-term thigh injury.
Leading goalscorer Jordan Rhodes, who has netted 23 times this season, and 16-goal Theo Robinson started against Colchester last week.
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