Southampton will welcome Rickie Lambert back into their starting line-up for the first time this season when they host Leyton Orient.
The striker, who hit 37 goals last term, sat out the opening-day defeat by Plymouth with a groin injury but proved his fitness with 10 minutes in the Carling Cup against Bournemouth last week.
Boss Alan Pardew has a strong squad to choose from with full-back Frazer Richardson (shoulder) and midfielder Oscar Gobern (hip) the only injury absentees.
Defender Radhi Jahdi, midfielder Morgan Schneiderlin and striker David Connolly were rested against the Cherries and should be involved.
Saints' previous league match against MK Dons was postponed following the sudden death of club owner Markus Liebherr last week.
Charlie Daniels is poised to return to the Leyton Orient starting line-up.
The defender suffered a knee injury in pre-season but has recovered quicker than expected and proved his fitness in a behind-closed-doors friendly against Reading this week.
Sunderland youngster Michael Liddle was drafted in for a month as cover for Daniels but he has missed the last two matches with a groin injury so Daniels should start
Midfielders Matthew Spring and Stephen Dawson and striker Alex Revell missed training earlier in the week with knocks and will be checked over.
Rookie striker Jake Argent, who signed his first professional contract this summer, is the only definite absentee with a long-term knee ligament problem.
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