Elliot Omozusi is an injury doubt for Leyton Orient ahead of the clash with Exeter.
The defender, a summer signing from Fulham, was forced out of Tuesday night's Carling Cup defeat by West Brom with a tight hamstring and will need a late fitness check.
Midfielder Jimmy Smith filled in at right-back against the Baggies following Omozusi's withdrawal.
Dean Cox, Matthew Spring and Alex Revell dropped out of the starting line-up as boss Russell Slade made changes for the cup clash and they should return.
Left-back Charlie Daniels could be pushed into a midfield berth once again.
Rookie striker Jake Argent, who signed his first professional contract this summer, is the only definite injury absentee with his long-term knee ligament problem.
Exeter are in the grips of a defensive injury crisis.
Skipper Matt Taylor is a doubt due to problems with back spasms, while Richard Duffy is serving a one-match ban following his sending off in last weekend's 2-2 draw with Bristol Rovers.
Troy Archibald-Henville would normally be an obvious replacement for Taylor but the game comes too soon for him after seven months on the sidelines with a knee injury.
Rob Edwards is expect to start in Taylor's place alongside Billy Jones at the heart of the defence, although should boss Paul Tisdale decide to revert to a 3-5-2 formation, Steve Tully could line-up as a right-sided centre-half with Jake Thomson at wing-back.
"It's a real headache," Tisdale told the Express & Echo. "We will have to decide what the plan is going to be because it is not ideal having that many defenders out."
"These things tend to come in little groups. We had a striker crisis this time last season and two years ago we had a central midfield crisis at the start of the season."
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