Bristol Rovers could be buoyed by the returns of Carl Regan and Dominic Blizzard ahead of the visit of Southampton.
Defender Regan and midfielder Blizzard were absent from last weekend's draw against Exeter with respective Achilles and hamstring injuries.
Byron Anthony picked up an knock in the game against the Grecians but is expected to be fit to start despite missing training earlier in the week.
Summer recruit Will Hoskins will lead the Rovers attack alongside Jo Kuffour - the former strike partner of Saints dangerman Rickie Lambert during his time as a crowd favourite at the Memorial Stadium.
Paul Trollope's men will be looking to build on their previous last-gasp 2-1 home win against Yeovil, while Saints are still looking for their first league victory of the season despite being many people's tip for promotion.
Guilherme do Prado should be involved for Southampton.
Boss Alan Pardew wanted to hand his new Brazilian midfielder, signed on an initial five-month loan deal from Italian side Cesena, his debut against Bolton in the Carling Cup on Tuesday but they did not receive international clearance in time.
Centre-half Dan Seaborne missed the 1-0 midweek defeat with a foot injury and remains a doubt while full-back Frazer Richardson is still on the sidelines with a shoulder injury.
Youngster Aaron Martin was chosen ahead of Radhi Jaidi at centre-back against Bolton and could keep his place after an impressive display.
Striker Lambert lines up against the club for whom he scored 59 goal in three years.
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