Frank Lampard will miss England's European Championship qualifiers against Bulgaria and Switzerland, with Peter Crouch and Bobby Zamora also being ruled as doubtful after a busy afternoon in Barclays Premier League.
Lampard, who limped off in the second half of Chelsea's 2-0 win against Stoke at Stamford Bridge, will undergo a hernia operation on Tuesday or Wednesday next week and is expected to be out for a fortnight.
Chelsea manager Carlo Ancelotti said: "It is a very easy surgery but he has started to feel pain and he needs to have the operation. We have already spoken with the national team to explain the situation."
Crouch, who had been tipped to earn a recall to Fabio Capello's squad when it is named on Sunday, following his midweek Champions League hat-trick, sustained a rib injury and may have broken a bone, which would rule him out of Friday's match against Bulgaria and the game in Switzerland four days later.
Tottenham boss Harry Redknapp said: "I think he might have done a rib; he was in agony at half-time.
"He's not sure if he's broken a rib or what he did but he was in pain."
And Zamora, who opened the scoring in the 2-2 draw against Blackpool - in front of Capello - became the third casualty, going off in the second half with a thigh injury.
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