Charlie MacDonald's first-half strike ended Sheffield Wednesday's unbeaten start to the season as Brentford won 1-0 to climb off the foot of the table.
MacDonald struck five minutes before the interval when he collected Craig Woodman's cross, swivelled and tucked a low shot past Nicky Weaver and into the net.
The Bees were previously without a win but fully deserved all three points.
Robbie Simpson had a shot cleared off the line by Mark Beevers and also struck the crossbar with a dipping volley, while Weaver pulled off a fine save to keep out substitute Nicky Adams' fierce drive.
Marcus Tudgay came closest for Wednesday but his shot was comfortably saved by Ben Hamer.
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms