Plymouth captain Carl Fletcher has handed boss Peter Reid a major boost by returning for the visit of Sheffield Wednesday.
Fletcher is back in full training following two games on the sidelines with a thigh problem and he is likely to go straight into the starting line-up.
Romain Larrieu, the club`s longest-serving player, will start his first league game of the season after loanee David Button returned to parent club Tottenham to receive treatment on an ankle injury picked up in the 0-0 draw with Colchester.
Elsewhere, Reid will be without Yala Balasie, who is still recovering from ankle surgery, and Rory Fallon after his hernia operation.
Luke Summerfield will also be missing with a swollen knee as Reid attempts to get the Pilgrims` season back on track after only one win in five league games.
Sheffield Wednesday striker Neil Mellor is hoping to return to the squad following tonsilitis.
Mellor, on a season-long loan from Preston, missed last week's home defeat to Carlisle but could be back in the starting line-up.
Boss Alan Irvine has plenty of options up front with Marcus Tudgay and summer signings Clinton Morrison and Paul Heffernan all available.
Winger Jermaine Johnson remains sidelined with his long-term knee injury but the Owls have no new injury or suspension problems.
Despite last week's defeat to Carlisle, which saw Wednesday slip from top to seventh in the table, Irvine is not expected to make too many changes.
Midfield pair Tommy Miller and James O'Connor, who both started on the bench last week, are pushing for recalls.
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