Shrewsbury will be without Benjamin van den Broek for their home game against Northampton.
The midfielder fractured his ankle while playing for the club`s reserves on Wednesday night and has been ruled out for between six to eight weeks.
Van den Broek was yet to start a league game for Town this term but had proved a reliable asset from the bench having made substitute appearances in all six games.
The Dutchman came on at half-time in last weekend`s 2-0 defeat at Gillingham - Shrews` first loss of the season which resulted in the club losing top spot in League Two.
Goalkeeper Chris Neal will be hoping the defeat does not jeopardise his place between the sticks with Ben Smith, who started the campaign as first choice, now fully fit again after a groin injury.
Defender Danny O'Donnell (groin) and striker Nathan Elder (knee) remain in the treatment room with long-term injuries.
Northampton midfielder Ryan Gilligan is set to play through the pain barrier once more.
Gilligan was set for three months on the sidelines when it was announced he would have surgery on an ankle problem but he has decided to postpone the operation and played the full 90 minutes against Southend last weekend.
Manager Ian Sampson said: "Ryan Gilligan is looking okay at the moment, he didn't train on Monday but he trained on Tuesday and he is happy to play through the pain.
"Like I said last week, fortunately for us Ryan has got the right attitude and it's nice to see that in the modern game."
Kevin Thornton came off the bench to inspire that victory and will be hoping to start while Leon McKenzie should continue up front after a bright debut last weekend.
Tadhg Purcell had an operation on his cruciate knee injury last week but is out for the season while left-back Marcus Hall is a fortnight away from returning from a hamstring injury.
Defender Craig Hinton remains on the sidelines with his knee problem.
Copyright (c) PA Sport 2009, All Rights Reserved.