Oxford manager Chris Wilder, fresh from signing a new three-year contract, is unlikely to have central defender Jake Wright back for the clash with Stockport.
Wright missed out at Hereford due to a stiff back while Damian Batt, who has sat out the last five games with an ankle injury, is still on the sidelines.
Wilder is likely to name the same side for the second consecutive game following the comfortable 2-0 victory over Hereford.
That means Harry Worley and Anthony Tonkin are set to play against their former club with Ben Purkiss and Mark Creighton joining them in the back four.
Oxford are on a four-game unbeaten run and have won the last two. They have also gone 371 minutes since conceding a league goal.
Stockport manager Paul Simpson could be boosted by the return of defender Robbie Williams for the trip.
The left-back has missed the last three games through injury and has not played since signing a full-time deal at Edgeley Park.
But the 25-year-old has returned to training this week and may come into contention to play some part.
Fellow defender Jordan Rose is also set to be passed fit after a recent injury to leave Simpson with a close to full-strength squad.
Simpson is still looking to strengthen his squad by signing a striker and a midfielder on loan.
The County boss said: "We're close to having a fully fit squad now but I'm still looking to bring players in."M
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms