Newcastle's Shola Ameobi sent 10-man Chelsea crashing out of the Carling Cup with a 90th minute goal to seal a 4-3 victory at Stamford Bridge.
Chelsea, who lost Salomon Kalou and Yossi Benayoun through injury, had taken a sixth-minute lead through young left-back Patrick Van Aanholt only for United to storm back and lead at the interval thanks to goals from Nile Ranger and Ryan Taylor.
Ameobi made it 3-1 to United before two goals from Nicolas Anelka (69, 86) looked to have taken the tie into extra time but Ameobi rose above Jeffrey Bruma to head the winner from a corner by Jonas Gutierrez.
Carling Cup holders Manchester United did not let absent boss Sir Alex Ferguson down as they came from behind to beat gallant Scunthorpe 5-2 at Glanford Park.
Ferguson reportedly chose to watch Champions League opponents Valencia instead, leaving Mike Phelan in charge, and there was plenty for the assistant manager to think about as Scunthorpe were rewarded for their terrific start by Josh Wright's superb 19th-minute strike.
But it took only four minutes for Darron Gibson to level and they were ahead before half-time through Chris Smalling, with two goals from Michael Owen and one from Park Ji-sung sealing victory in the second half. Scunthorpe got the second goal they deserved in injury-time from the impressive Martyn Woolford.
Gerard Houllier marked his first match as Aston Villa boss with a victory as two goals from Ashley Young and substitute Emile Heskey inspired a 3-1 win over Blackburn.
Rovers were the better side in the first half and deservedly led at the interval through Gael Givet's stunning strike.
But Heskey levelled matters with his first touch after 59 minutes and then Young struck twice in quick succession to see Villa - last season's beaten finalists - reach the last 16.
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