Marlon King is expected to make his long-awaited Coventry debut when Preston visit the Ricoh Arena.
The striker finally completed his move to the Sky Blues on Monday and could start against North End having maintained his fitness while training over recent weeks and taking part in reserve games.
His arrival is not the only piece of good news for manager Aidy Boothroyd who is also boosted by the availability of Danny Ward (calf), Michael McIndoe, David Bell and Gary McSheffrey (all hamstring) after injury.
However, despite the return of his influential midfield quartet, Boothroyd remains without at least seven professionals including the likes of Freddy Eastwood, James McPake, Gary Deegan, Chris Hussey and Stephen O`Halloran.
City will be looking to build on last weekend`s 2-1 win at Bristol City and maintain their unbeaten home record against a struggling North End side reeling from five successive defeats.
Preston boss Darren Ferguson is boosted by the availability of striker Iain Hume.
The on-loan Barnsley frontman was ineligible for Wednesday's Carling Cup defeat at Wigan having played in the competition in an earlier round for his parent club.
He will now come back into contention and may earn a starting role as Ferguson's men bid to arrest their dismal slump in form.
Winger Keith Treacy succumbed to injury in the second half at the DW Stadium and will be assessed while defender Callum Davidson missed out with a calf strain.
Both players may miss out while on-loan Manchester United duo Matt James and Josh King are also expected to remain sidelined with ankle injuries.
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