Chesterfield manager John Sheridan has promised changes to his side for the visit of Crewe.
One change could be enforced after Drew Talbot suffered a broken nose during the midweek victory at Northampton.
The forward is a doubt along with midfielder Mark Allott, who missed the match at Sixfields with the hamstring problem that forced him off at half-time in the defeat at Rotherham last weekend.
"The team that won the game on Tuesday night will not be the team that plays on Saturday," said Sheridan.
Jack Lester looks likely to start after the veteran striker`s introduction from the bench at Northampton swung the game in Chesterfield`s favour.
Ajay Leitch-Smith is in contention to make his first start of the season.
The 20-year-old striker has scored twice in three substitute appearances this season, most recently to earn Alex a point against Macclesfield on Tuesday night.
He then added strength to his claims for a starting role by scoring two goals for the reserves the following day.
"Ajay is definitely in contention for his first start," said Alex assistant manager Steve Davis. "We are struggling to take chances, so we can't ignore that Ajay is staking his claim."
Joel Grant could be a doubt after he was substituted at half-time against Macclesfield.
Crewe extended their unbeaten league run to seven games against the Silkmen, however, five of those have been 1-1 draws.
Copyright (c) PA Sport 2009, All Rights Reserved.