Oxford manager Chris Wilder looks set to restore striker James Constable to the starting line-up for the home match against Port Vale.
Constable has scored seven times already this season but missed Tuesday's 1-1 draw with Cheltenham through suspension.
The return of Constable compensates for the loss of defender Mark Creighton who fractured his toe in midweek and has been ruled for two weeks.
Defender Anthony Tonkin could return after illness ruled him out against the Robins, but Jake Wright (back), Damien Batt (ankle) and Rhys Day (knee) are still sidelined.
United will be looking to get back to winning ways after going three games without a victory but it will be tough against npower League Two table toppers Vale.
Vale will likely field the same starting XI as the one which saw off fellow high-flyers Shrewsbury in midweek.
Manager Micky Adams named the same side which saw off Accrington four days earlier for the top-of-the-table clash against their local rivals and he is unlikely to see any need for change at the Kassam Stadium.
The only factor which may come into play is tiredness after a hectic schedule of late and Adams will assess the state of his squad.
Louis Dodds has been on the periphery of late, despite contributing with some impressive displays, and he could start should Adams opt to mix it up.
Boasting a club-record five successive clean sheets, goalkeeper Stuart Tomlinson and defenders Adam Yates, John McCombe, Gareth Owen and Lee Collins will be out to continue Vale`s defensive resilience.
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