Mick McCarthy has already spoken this week of his belief that Wolves can use this weekend's game at the DW Stadium as a platform to get back to winning ways.
It certainly does represent the best chance of a positive result since the 1-1 draw with Newcastle at Molineux at the end of August.
Wolves should be in more confident mood after a fantastic second half display against Aston Villa that almost saw them grab a point. Matt Jarvis in particular will be looking to back up his display last weekend with another solid performance after strong rumours of an England call up.
But, not all is well in the Molineux camp; Adlene Guedioura will be sidelined for a lengthy period having suffered a broken leg only minutes into his substitute appearance against Villa and summer signing Jelle Van Damme has expressed difficulty settling in since his arrival from Belgium.
These kinds of problems are common in the modern game and McCarthy has the nous and experience to deal with them whilst still pushing his side forward and keeping them positive - which couldn't be more important going into a 'crunch' game so early in the season.
Wigan have had an indifferent start to their season, shockingly losing 0-4 at home to Blackpool on the opening day, yet securing all three points at White Hart Lane - and their manager Roberto Martinez will be keen to turn their fortunes around against Wolves.
Wigan have dangerous players that, last season, showed that they can and will punish you unless you keep your concentration right up to the final whistle.
This season, Wigan have struggled defensively. They have the worst goal difference in the league courtesy of the 0-4 loss to Blackpool, the 0-6 loss to Chelsea and the 0-2 loss to Manchester City. Worryingly for Roberto Martinez, their biggest defeats this season have come at home.
Wolves certainly have the attacking talent to worry a shaky Wigan defence and defensively themselves they should be able to do a good job of containing any threat from the opposing strikers; an attack that has scored only two goals this season.
But, anything can happen in football, so Wolves will have to play well and keep their heads to take all three points.
Disclaimer: The views in this article are that of the writer and may not replicate those of the Professional Footballers' Association.