Rangers suffered their first defeat in the Champions League this season as Roberto Soldado grabbed a double to help hand Valencia a 3-0 victory at the Mestalla.
He netted on both sides of the interval, before Tino Costa sealed the win late on, as the Spaniards leapfrogged Rangers into second place in Group C, with Manchester United strengthening their grasp on top spot with a win over Bursaspor.
Steven Naismith hit the woodwork twice on a frustrating night for Walter Smith's men as they failed to produce the fightback to maintain their unbeaten run in the competition.
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