Rooney, who recently ended speculation regarding his future by penning a new five-year contract, is set to miss the midweek encounter.
The Red Devils had hoped that the 24 year old would recover from an ankle problem in time to face arch-rivals Manchester City at Eastlands on Wednesday.
Rooney has not figured for United since their 2-2 draw with West Brom on 16th October, with matters off the field having dominated the headlines since then.
Shortly after that fixture it emerged that the England international was keen to leave Old Trafford, causing chaos within the media with even his own fans turning against him.
That issue was soon laid to rest as he opted to pen a new deal but he is yet to make an appearance since news of his desire to leave the club broke.
It's unclear when Rooney will play again but he is due back from the States on November the 13th, when it is hoped he will be fit to play again.
United assistant manager Mike Phelan confirmed the plan for Rooney: "What we are intending to do with Wayne is send him to Nike Town in the USA for a week's conditioning training."
Disclaimer: The views in this article are that of the writer and may not replicate those of the Professional Footballers' Association.