Southport`s big day was ruined by a ruthless display of finishing from Sheffield Wednesday as an amazing second-half flurry of goals saw the game end 5-2 to the League One side.
The Blue Square Bet Premier side equalised twice shortly after the interval, but ultimately the Owls` superior class and fitness won the day.
Clinton Morrison scored twice for the Yorkshiremen with Gary Teale, Neil Mellor and Tommy Spurr also finding the net while Paul Barratt and Matty McGinn replied for their Merseyside rivals.
Teale bagged Wednesday's opener in the 11th minute as he latched onto Morrison's low cross across the six-yard box.
Southport got their dream leveller in the 52nd minute when ex-Liverpool trainee Barratt tucked home, but Mellor put Wednesday back in front a minute later with a close-range finish.
Substitute Matty McGinn rifled in dramatically with his first kick to get the home side level again, but then Wednesday cut loose.
Morrison scored two quick goals inside three minutes - the first into the top corner from close in and the second a well-taken drive into the bottom corner - before left-back Spurr tapped home to make it 5-2 in the 64th minute.
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