Rotherham manager Ronnie Moore will hope to have a new defensive loan signing in place when Oxford visit Don Valley.
The Millers are struggling for numbers as right-back Johnny Mullins faces two weeks out with a calf injury while Nick Fenton picked up a knock in the midweek defeat against Huddersfield and remains a doubt.
Moore has targeted a Premier League or Championship replacement but if he is unable to bolster his squad then midfielder Danny Harrison is set to fill in at right-back.
Moore's problems are not restricted to defence, however, as striker Ryan Taylor suffered a knee injury on Tuesday and faces a race against time to be fit while star man Adam Le Fondre has been laid low with a bout of sickness but returned to training on Thursday and should be OK.
Stephen Brogan is hoping to earn a first league start since February on the left of midfield, with Tom Newey set to return at left-back.
Oxford manager chris Wilder has three new players at his disposal for the trip.
Wilder has moved fast during the week to tie up loan deals for a trio of players who have a vast amount of Football League experience.
Defender Ben Futcher has joined from Bury, midfielder Paul Wotton has arrived from Southampton and striker Steven Maclean has signed from Plymouth and all three new signings are in contention to make their debuts against Ronnie Moore's men.
Jake Wright is unavailable as he serves the final game of his three-match suspension while Sam Deering and Asa Hall are both pushing for a start after their goals in midweek for the reserves.
Striker James Constable should return to the squad after missing the FA Cup defeat to Burton through illness. M
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