Cesc Fabregas will be out for another fortnight with the hamstring injury he picked up against Braga in the Champions League.
Goalkeeper Manuel Almunia suffered a setback to his elbow injury in training and also misses the match against Fulham.
Samir Nasri and Sebastien Squillaci have recovered from knee injuries but Abou Diaby (ankle) and Thomas Vermaelen (Achilles) are still not available.
Striker Marouane Chamakh should start and has targeted the 20-goal mark in his first season at Arsenal.
The Moroccan has impressed since a free transfer summer move from Bordeaux, with his strike at Aston Villa last weekend taking the tally into double figures.
"For me, if I can weigh in with 15 to 20 goals, it would be a very, very good season," he said.
"Whatever happens I hope to continue my progress.
"It has gone really well with the set-up here, I hardly knew anyone when I arrived, but they have all made me feel very welcome.
"It has been easy to settle in and this has allowed me to express myself and that's very important.
"Personally, I am happy, but I can do better."
Andrew Johnson is set to return to the Fulham.
Striker Johnson sat out last weekend's 1-1 draw against Birmingham with a hamstring strain, having made his first start since his 10-month injury lay-off in the previous game against Manchester City.
Carlos Salcido is out after suffering a recurrence of an ankle problem at St Andrews, while Mousa Dembele (ankle), Bobby Zamora, Rafik Halliche (thigh), Frederik Stoor (groin) and Phillipe Senderos (Achilles) are also unavailable.
Fulham have been boosted by the news goalkeeper Mark Schwarzer has signed a new contact.
The Australian looked certain to leave after expressing a desire to join the Gunners, and his u-turn speaks volumes for new manager Mark Hughes' powers of persuasion.
Hughes said: "I just sat him down and said, for myself and for Fulham to be successful, I need Mark Schwarzer here.
"That's basically it, in black and white terms.
"He's an outstanding keeper and has been for many, many years.
"He understands the Premier League, he understands what it's all about and we're a better team when Mark Schwarzer's playing.
"It was very easy from my point of view to construct an argument because it's there for everybody to see."
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