Saturday afternoon's Barclays Premier League game between Wigan and Aston Villa is in "serious doubt" after heavy snow overnight, the Latics have said.
The north-west club issued a statement describing the surrounding conditions as "treacherous" and warning the match, scheduled to kick off at 1500 GMT at the DW Stadium, could be called off.
"The game is in serious doubt after heavy snow overnight," it read. "Despite the best efforts of the club to keep the game on by bringing in snow ploughs and gritters, the game against Aston Villa is now in serious doubt after 10 inches of overnight snowfall."
The statement continued: "Public transport isn't running, there are motorway closures and the general condition of the surrounding routes is treacherous."
In the npower Championship, Cardiff's match against Burnley fell foul of the latest big freeze on Friday night following heavy snowfall in south Wales.
The League One games at Rochdale, Walsall, Hartlepool, Leyton Orient, Plymouth, Yeovil and Brentford are also off, along with those at Bury, Accrington and Hereford in League Two.
In Scotland, Hamilton's home game against Celtic became the fourth casualty in the Clydesdale Bank Premier League after the Rangers-St Mirren, Aberdeen-Motherwell and St Johnstone-Dundee United clashes were postponed on Friday.
Nine other games in the Scottish leagues have also been called off.
The weather is also playing havoc with racing, with all but two of Saturday's meetings definitely off. Ascot, Newcastle and Haydock have been frozen out while Lingfield faces a further inspection.
Carlisle's meeting on Sunday has already bitten the dust.
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