MK Dons will begin life without striker Aaron Wilbraham when they host managerless Bristol Rovers.
Wilbraham has completed a surprise move to Championship high-fliers Norwich after a five-and-a-half year spell with the Dons, and leaves one goal short of hitting his 50th league strike.
However, manager Karl Robinson has been boosted by the return to fitness of Sam Baldock. The striker had been absent with an ankle injury but made his comeback as a late substitute in the 2-0 win over Bournemouth on Tuesday and could start.
Midfielder Peter Leven also returned against the Cherries after a groin strain while defender Sean O`Hanlon was back from compassionate leave.
On-loan QPR striker Angelo Balanta will be out of action until March with an ankle injury and utility player Jude Stirling is nearing a return to action after a groin strain but will not make the squad.
Plymouth will be without winger Craig Noone following the skipper's sale to Brighton.
Noone has been signed by npower League One pacesetters Brighton for an undisclosed fee, so Chris Clark and Karl Duguid could both come into contention.
Carl Fletcher returned from a thigh injury in Tuesday's 1-1 draw with Notts County and will retain the captain's armband and fellow midfielder Jim Paterson played the full 90 minutes following his return from a hamstring strain.
Manager Peter Reid will be hoping defender Onismor Bhasera and midfielder Kari Arnason, who both played against Notts County, have shaken off illness.
Argyle are unbeaten in their last three league matches and although currently in 15th place in the table, are only four points adrift of the play-offs.
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