Tranmere have made a trio of new signings ahead of the home clash with Walsall and all three could be handed debuts.
Defender Mark McChrystal has joined from hometown club Derry City where he has spent the last three seasons.
Rovers have also completed the one-month loan signing of Sunderland defender Michael Kay and veteran goalkeeper Tony Warner has signed until the end of the season.
Warner looks set to line up between the post after on-loan stopper Gunnar Nielsen returned to Manchester City.
In another boost, Rovers have agreed a deal to keep on-loan West Brom striker Lateef Elford-Alliyu for another month
Defender Marlon Broomes serves the second match of a three-game ban following his dismissal in the defeat at Rochdale last weekend.
Dean Smith takes charge of his first game as Walsall caretaker manager on the Wirral.
Head of youth Smith has taken the reins this week following the dismissal of Chris Hutchings and assistant Martin O'Connor, with physio John Whitney assisting him at Prenton Park.
Victory would enhance Smith`s chances of possibly being awarded the position on a full-time basis and give the Saddlers a much-needed boost in their bid to climb out of the relegation zone, with the club eight points adrift of fifth-bottom Rovers.
Smith will assess goalkeeper Jimmy Walker ahead of the encounter as he completes his recovery from a hamstring injury.
Midfielder Richard Taundry has missed the last two games with an ankle injury and will again sit out while striker Darren Byfield (knee) is also missing but nearing his long-awaited return.
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