Southampton came up with an FA Cup third-round shock of sorts as they sank a second-string Blackpool side 2-0 at St Mary's.
Second-half goals from Lee Barnard and Guly Do Prado secured a deserved win for the League One outfit, who also rattled the woodwork twice.
But Seasiders boss Ian Holloway, whose sole focus is surviving in the Premier League, made nine changes to his line-up and spared his established stars the long trip south.
Everton stated their determination to win the FA Cup by powering into the fourth round with an emphatic 5-1 win over Championship strugglers Scunthorpe.
Louis Saha and Jermaine Beckford got the Merseysiders off to a flying start at Glanford Park before Seamus Coleman, Marouane Fellaini and Leighton Baines made sure of victory.
Scunthorpe were completely outplayed aside from a brief spell at the start of the second half when Michael Collins threatened to spark a comeback with a superb strike.
Diomansy Kamara scored his first hat-trick in English football as Fulham proved they were serious about another crack at the FA Cup this season after sweeping past Peterborough 6-2.
Quarter-finalists for the last two years, the Cottagers resisted the urge to rest players despite their Barclays Premier League relegation battle and duly demonstrated the true gulf in class between the top flight and npower League One.
Dickson Etuhu and substitutes Zoltan Gera and Jonathan Greening also found the net, while Lee Tomlin and a Grant McCann penalty salvaged some pride for the visitors, who survived an even heavier beating.
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