Jon Taylor and Matt Harrold secured a 2-0 win for Shrewsbury as they halted Southend's three-match winning streak.
Taylor grabbed a brace on Tuesday in his first league start, with Harrold getting the other goal in a 3-1 win over Burton Albion.
And it was Taylor who broke the deadlock at Roots Hall after Harrold picked up a stray Blair Sturrock pass and released Taylor, who fired in the bottom left-hand corner in the 42nd minute.
Former Southend striker Harrold doubled the advantage on the hour when James Collins latched onto a ball over the top and teed up his strike partner who unleashed a left-footed shot into the right of the goal.
Harrold had earlier had a header saved by Southend goalkeeper Rhys Evans, while the custodian saved a header from six yards from substitute Tom Bradshaw in the 90th minute.
Southend had efforts off target but their only shots on goal came from Ryan Hall's curling effort which was saved by Shrews goalkeeper Ben Smith in the first half and a tame Craig Easton effort that Smith comfortably dealt with.
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