Oxford boss Chris Wilder could hand Simon Hackney his home debut against Rotherham.
The winger has impressed during his two outings so far, both as a substitute in the away games with Southend and Gillingham, and could be handed his first start in front of his home fans.
Midfielder Josh Payne is a doubt with an ankle injury sustained when he was on the receiving end of a bad tackle in the 3-0 midweek reserve-team defeat against Ipswich.
Defender Simon Batt, meanwhile, will definitely miss out as he serves the second game of a three-match ban following his red card during the 2-1 defeat at Southend on February 1.
The U`s will be looking to end a run of three league games without a win.
Winger Omar Daley could be handed his Rotherham debut when Ronnie Moore's side travel to the Kassam Stadium.
The 29-year-old Jamaica international will go straight into the Millers squad to face the Us following his arrival on loan from Bradford until the end of the season.
However, Kevin Ellison will not be available for selection following his move in the opposite direction on a similar deal.
Goalkeeper Andy Warrington is the only fresh injury worry but he should be fit to retain his place between the sticks despite a cut head suffered during the 3-1 defeat at Gillingham in midweek.
Jamie Annerson will be on standby just in case the 34-year-old fails to recover in time.
Skipper Ryan Cresswell is making good progress on his return from a broken collarbone but is still weeks away from a return to first-team action.
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