Plymouth boss Peter Reid will again be without Jim Paterson, Onismor Bhasera and Yala Bolasie for the important clash with fellow relegation battlers Tranmere.
Paterson missed the defeats to Yeovil and Brentford as he was on compassionate leave and will be absent again although he will return to training on Monday.
Bhasera is making good progress in his rehabilitation from a knee problem but the game will come too soon for him while Bolasie will sit out the second of a three-match ban following his sending-off against Yeovil on February 1 for an off-the-ball incident.
However, top goalscorer Joe Mason is set to continue in attack after getting through his comeback from an ankle injury against Brentford unscathed.
The Pilgrims will be attempting to end a run of four successive league defeats.
Rovers boss Les Parry has been handed a triple injury boost.
Tim Cathalina, Alan Mahon and Zoumana Bakayogo all played 90 minutes for the reserves in a behind-closed-doors friendly against Liverpool in midweek.
The trio's return to fitness has encouraged hopes that they will be available to play some part against the Pilgrims.
Winger Andy Robinson is nursing a slight calf strain, but Parry said: "That looks like it's going to be okay."
However, midfielder Ryan Fraughan has damaged medial ligaments in his knee and will be out for around six weeks.
Rovers have extended the loan of Lateef Elford-Alliyu from West Brom by one month meaning the 18-year-old striker will stay at Prenton Park until early March.
Copyright (c) PA Sport 2009, All Rights Reserved.
Do YOU want to write for GiveMeSport? Get started today by signing-up and submitting an article HERE: http://gms.to/writeforgms