LIVE TEAM SHEET
WALES: 1 Wayne Hennessey, 2 Chris Gunter, 3 Danny Collins, 4 Andrew Crofts, 5 James Collins, 6 Ashley Williams, 7 Joe Ledley, 8 Craig Bellamy, 9 Steve Morison, 10 Aaron Ramsey (C), 11 Andy King.
SUBS: 12 Boaz Myhill, 13 Neal Eardley, 14 Danny Gabbidon, 15 David Vaughan, 16 Joe Allen, 17 Simon Church, 18 Ched Evans.
ENGLAND: 1 Joe Hart, 2 Glen Johnson, 3 Ashley Cole, 4 Scott Parker, 5 Michael Dawson, 6 John Terry (C), 7 Frank Lampard, 8 Jack Wilshere, 9 Darren Bent, 10 Wayne Rooney, 11 Ashley Young
Substitutes: 12 Robert Green, 13 Phil Jagielka, 14 Joleon Lescott, 15 James Milner, 16 Stewart Downing, 17 Jermain Defoe, 18 Andy Carroll
As with every big game there are key match-ups that will decide the contest, and this Saturday's Euro 2012 qualifier between Wales and England is no different.
Many of these players have met before in the Premier League, but in the pressure cooker of a international match at the Millennium Stadium, these perhaps predictable regular season match-ups have been given extra spice.
Here's a couple of the key duels that could determine where the points go on Saturday afternoon.
Ashley Williams vs Wayne Rooney
There's no need to ask Rio Ferdinand what it feels like to be snubbed as international captain, Wales' Williams will give you a pretty accurate description of the feeling.
Overlooked for the armband, which was handed to Aaron Ramsey, the Swansea City defender will be keen to prove he has what it takes to play in the Premier League against England's talisman Rooney.
The 25-year-old meanwhile has scored just one international goal in 18 months and will be keen, as ever, to showcase his talent after a poor season by his standards. Away from the battle between the two 6 ft 4in titans James Collins and Andy Carroll, these two have much to prove.
Aaron Ramsey vs Jack Wilshere
Apart from Gareth Bale, these two are arguably the most exciting young prospects in British football right now, and for Ramsey, the honour of being handed the captaincy on the eve of this mammoth clash will work as even greater motivation to make an impact against his club team-mate.
The pair might hail from Caerphilly and Stevenage, but their style of play would be more at home in Barcelona. Both will control the midfield, begin attacks and deny space for those looking for goal. While we might not see either venture too far past the half-way line, their contributions in their own halves could be the difference.
Steve Morison vs John Terry
It you go back nearly four years Millwall's Morison was firing his Stevenage Borough side to victory in the FA Trophy final, while just seven days later Chelsea's Terry was lifting the FA Cup after the first final at the new Wembley against Manchester Untied.
On Saturday at the Millennium Stadium the two will meet for the first time as their contrasting careers collide in Cardiff. Very much like Collins vs Carroll at the other end, expect this to be a genuine physical battle.
Morison has bullied most in the football league, but toppling the England captain is a different proposition. Terry can't boast to being in the greatest of form at present but he'll pose more than a test for the 27-year-old.