Oxford will have midfielder Paul McLaren available to face Burton.
McLaren had to come off after 61 minutes of the 2-1 win over Crewe last Saturday with a groin injury but has been passed fit.
Assistant manager Mickey Lewis said: "From last weekend, Paul McLaren had a bit of a groin problem but that's cleared up.
"We've got everybody fit and available, which is great news."
New signing Ryan Doble is away on international duty with Wales Under-21s so misses out while three players who have been made available for transfer will not feature.
Simon Clist, Ben Purkiss and Steve Kinniburgh have been told they can leave while Jack Midson signed for Barnet last week.
Burton boss Paul Peschisolido will be without John McGrath.
The midfielder picked up his 10th yellow card of the season against Stevenage on Tuesday night and will be suspended for two matches.
Defenders Paul Boertien and Nathan Stanton (both groin) are unlikely to be fit to travel to the Kassam Stadium.
On-loan left-back Scott Malone faces a late fitness test after being forced out of Tuesday's game with a hamstring problem.
If Malone misses out his place could go to Leicester defender Tom Parkes, who has rejoined the club on loan until the end of the season.
The 19-year-old centre-back spent the second half of last season on loan with the Brewers, making 22 appearances and scoring one goal.
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