Wolves midfielder David Edwards has withdrawn from the Wales squad for next week's Carling Nations Cup matches.
Edwards has not played since February due to a back injury but had been named in Gary Speed's initial party for the games against Scotland and Northern Ireland in Dublin.
The 25-year-old has endured a difficult season due to thigh, hamstring and back problems but will now hope to be fit for the start of next season.
Edwards' withdrawal follows those of Lewin Nyatanga and Ched Evans due to injury and of four players involved in the npower Championship play-off final - Ashley Williams, Joe Allen, Simon Church and Hal Robson-Kanu.
With Coventry's Freddy Eastwood also doubtful, Speed has bolstered numbers by calling in Norwich midfielder Owain Tudur Jones.
The 26-year-old, who spent the second half of the season on loan at Brentford, could now win his first cap for two years having been overlooked in recent times.
Craig Morgan, Andy Dorman and Jermaine Easter were drafted into the squad last week.
Wales, who lost their opening Nations Cup match to the Republic of Ireland in February, face Scotland on Wednesday and Northern Ireland 48 hours later. Both games are at the Aviva Stadium in Dublin.
Speed, still looking for his first win since taking charge, has said he intends to rotate his squad.
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