Leyton Orient will be without Jonathan Tehoue for the visit of Tranmere.
The French striker starts a three-match ban after he was sent off during Tuesday night's penalty shoot-out win at Southend in the Carling Cup.
Orient will hand fitness tests to skipper Stephen Dawson, fellow midfielder Marc Laird and striker David Mooney.
Dawson (ankle) and summer signings Laird (thigh) and Mooney (hamstring) are edging closer to fitness after missing the first two games of the season.
But midfielder Leon McSweeney is out for up to a month with the knee injury he suffered against Walsall on Saturday and Jamie Jones is still missing with a shoulder problem so Lee Butcher, who saved two penalties in midweek, continues in goal.
Tranmere boss Les Parry will assess the fitness of defender Mark McChrystal.
The Irishman limped off after just over an hour of Tuesday's 3-0 Carling Cup first-round defeat at Doncaster with a pelvic injury.
He was replaced by former Liverpool trainee David Raven, who joined Rovers on a one-year contract last week and is set to compete with Ash Taylor for a centre-back berth should McChrystal be ruled out.
Parry could hand fit-again striker Enoch Showumni a starting role after he came off the bench at Doncaster.
The boss said: "Mark (McChrystal) has been having some lower back problems and when he came off, it was his thigh he was pointing to. But it is the whole of the pelvic area he is struggling with."
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