Arsenal welcome Liverpool to the Emirates Stadium on Saturday, with Arsene Wenger missing several key senior players.
Cesc Fabregas finally joined Barcelona this week, while Samir Nasri is said to be on the verge of joining Manchester City.
Wenger is also without Jack Wilshere, Kieran Gibbs and Johan Djourou, as well as suspended pair Gervinho and Alex Song.
For Liverpool the only injury issues remain with Steven Gerrard and Glen Johnson.
Chelsea play West Brom on Saturday evening, with Andre Villas-Boas desperate for his first win as Blues boss.
New signing Romelu Lukaku is available, while Hilario will deputise for the injured Petr Cech.
Sunday sees Manchester City travel to Bolton, with both teams coming off the back off 4-0 victories in the first week of the season.
Reigning Barclays Premier League champions Manchester United are not in action until Monday, when they take on Tottenham at Old Trafford.